Buy 3-HO-PCE Powder Online | High-Purity Hydroxylated Arylcyclohexylamine Research Chemical

Introduction to Buy 3-HO-PCE Powder

Buy 3-HO-PCE Powder (3-Hydroxyeticyclidine), designated in pharmacological literature as a novel synthetic arylcyclohexylamine, is a highly potent research chemical and a critical reference standard in neuropharmacological and forensic research. Structurally, it is the 3-hydroxy analog of PCE (Eticyclidine) and the direct de-alkylated metabolite of the widely documented 3-MeO-PCE.

In neuropharmacological and forensic research, 3-HO-PCE is paramount because it represents the primary active metabolite of 3-MeO-PCE. When 3-MeO-PCE undergoes first-pass hepatic metabolism, the 3-methoxy group is rapidly O-demethylated by cytochrome P450 enzymes to form 3-HO-PCE. Providing researchers with the pre-formed hydroxy analog allows for the isolation of this specific molecule’s pharmacology without the confounding variables of in-vivo metabolism. 3-HO-PCE functions as a potent non-competitive NMDA receptor antagonist, binding to the PCP site within the NMDA receptor complex and blocking glutamate-gated ion channels. Supplied as a stable hydrochloride (HCl) crystalline powder, this format offers exceptional versatility for laboratories requiring custom volumetric dosing for in-vitro assay preparation and analytical calibration. Note: This product is strictly intended for in-vitro research and analytical purposes only.

Key Features and Benefits – Buy 3-HO-PCE Powder

• Raw Powder Versatility: Supplied as a pure, crystalline powder, this format allows researchers to create precise, custom-concentration volumetric solutions tailored to unique in-vitro assay requirements, eliminating the variables of pre-mixed liquids or fixed-dose units.
• Active Metabolite Profiling: 3-HO-PCE provides researchers with the exact molecular structure of 3-MeO-PCE’s primary active metabolite, essential for isolating and studying the specific receptor binding kinetics and efficacy of the hydroxylated phenotype.
• Hydroxy vs. Methoxy SAR Mapping: Allows for direct comparative structural-activity relationship (SAR) studies against 3-MeO-PCE and 3-Fluoro-PCE, mapping how increasing polarity (hydroxy) versus lipophilicity (methoxy/fluoro) dictates NMDA receptor affinity and blood-brain barrier penetration rates in vitro.
• Metabolic Pathway Calibration: Essential for mapping the O-demethylation and subsequent glucuronidation pathways of methoxylated arylcyclohexylamines using hepatocyte cultures and liver microsomes.
• HCl Salt Stability: Supplied as a stable hydrochloride salt, ensuring exceptional physical stability, precise measurability, and safe handling compared to unstable freebase oils.
• Analytical Standard: Foremost reference standard for forensic laboratories requiring pure, verified materials to validate LC/MS and GC/MS instruments and confirm the ingestion of 3-MeO-PCE via metabolite detection in biological matrices.

Product Specifications

• Chemical Name: 2-(3-hydroxyphenyl)-2-(ethylamino)cyclohexan-1-one hydrochloride
• Common Designation: 3-HO-PCE / 3-Hydroxyeticyclidine
• CAS Number: Refer to Certificate of Analysis
• Class: Arylcyclohexylamine / Hydroxylated NMDA Antagonist / Research Chemical
• Form: Crystalline Powder (Hydrochloride Salt)
• Purity: ≥ 98% (Verified by Independent Third-Party Testing)
• Appearance: White to off-white fine crystalline powder
• Storage Requirements: Store in a cool, dry, dark environment (ideally -20°C for long-term archival). Keep container tightly sealed under inert gas to prevent hygroscopic absorption and oxidation. Crucial: Hydroxylated compounds are more prone to oxidation than their methoxy counterparts.
• Solubility: Freely soluble in water, DMSO, and ethanol.

Applications and Usage

3-HO-PCE Powder is exclusively designated for in-vitro (outside a living organism) research and analytical applications. Common laboratory applications include:

• Active Metabolite Profiling: Investigating the receptor affinity and efficacy of 3-MeO-PCE’s primary active metabolite at the PCP binding site on the NMDA receptor, isolating its pharmacokinetics from the parent compound.
• Hydroxy vs. Methoxy SAR Studies: Contrasting the pharmacokinetic properties and receptor conformational changes induced by 3-hydroxy substitution (3-HO-PCE) versus 3-methoxy substitution (3-MeO-PCE) to map the steric and electronic limits of the receptor binding pocket.
• Metabolic Pathway Studies: Analyzing the hepatic O-demethylation of 3-MeO-PCE and the subsequent phase II glucuronidation of 3-HO-PCE using hepatocyte cultures and liver microsomes.
• Forensic and Analytical Calibration: Utilizing 3-HO-PCE as a certified reference material (CRM) for GC/MS, LC/MS, and NMR spectroscopy to validate analytical instruments and confirm 3-MeO-PCE ingestion via metabolite detection in biological matrices.

Disclaimer: This product is not for human or veterinary consumption. It must only be handled in controlled laboratory environments by qualified professionals.

Purity and Testing

We guarantee a purity level of ≥ 98% for our 3-HO-PCE Powder. Every batch undergoes rigorous, independent third-party testing to verify chemical identity, absolute purity, and the absence of dangerous residual solvents, heavy metals, or unreacted precursors. Because arylcyclohexylamines are a heavily counterfeited class, we perform exhaustive screening to ensure the absolute absence of dangerous contaminants (such as 3-MeO-PCE, PCE, Ketamine, or synthetic opioids). Crucially, because hydroxylated arylcyclohexylamines are susceptible to oxidation, special analytical care is taken to ensure minimal presence of quinone degradation products. Certificates of Analysis (CoA) and Safety Data Sheets (SDS) are provided upon request.

Safety and Handling

WARNING: 3-HO-PCE IS A HIGHLY POTENT NMDA ANTAGONIST AND CENTRAL NERVOUS SYSTEM DEPRESSANT. EXTREME CAUTION IS REQUIRED.

• Personal Protective Equipment (PPE): Always wear appropriately sized nitrile gloves, chemical-resistant safety goggles, and an N95 or P100 particulate respirator when weighing or transferring the powder.
• Ventilation: Handling must only occur within a certified chemical fume hood to prevent the inhalation of aerosolized particles.
• Accidental Exposure: In the event of skin contact, wash the area thoroughly with soap and water. For eye contact, flush with copious amounts of water for at least 15 minutes.
• Hygiene: Remove contaminated clothing immediately and wash hands thoroughly after handling, even when PPE is utilized.
• Secure Storage: Keep powder locked away in a secure, access-controlled laboratory cabinet, out of reach of unauthorized personnel.

Global Shipping and Discreet Delivery

• Global Reach: We ship 3-HO-PCE Powder internationally, in strict compliance with international shipping regulations.
• Discreet Packaging: All orders are dispatched in unmarked, tamper-evident, and odor-proof packaging. The outer packaging does not indicate the nature of the contents.
• Rapid Processing: Orders are processed and shipped within 24 hours of cleared payment. We offer standard and express courier options with full end-to-end tracking.
• Secure Handling: Powders are double-sealed in moisture-barrier bags and placed within sturdy outer containers to prevent damage during transit.

Why Choose Us To Buy 3-HO-PCE Powder?

• Uncompromising Quality: We work directly with top-tier chemical synthesis laboratories and verify every batch in-house and via third-party labs before it reaches you.
• Total Transparency: We provide full analytical data. What is on the label is exactly what is in the bag—no fillers, no impurities, no compromises.
• Expert Customer Support: Our support team understands the nuances of research chemicals and is ready to assist with CoA requests, shipping inquiries, and technical questions.
• Secure Transactions: We utilize SSL encryption and accept secure, discreet payment methods, including major cryptocurrencies (Bitcoin, Monero, Ethereum) and secure bank transfers.

Legal and Safety Compliance

3-HO-PCE Powder is sold strictly as a research chemical and is not approved by the FDA, EMA, or any equivalent regulatory body for human or veterinary use.

It is the sole responsibility of the purchaser to ensure that the acquisition, possession, and use of 3-Hydroxyeticyclidine comply with all local, state, national, and international laws. Warning: 3-HO-PCE is a potent central nervous system depressant and NMDA antagonist. Ingestion can cause severe, life-threatening psychological and physiological effects, including profound dissociation, respiratory depression, and severe psychological distress. As an active metabolite and structural analog of PCE and PCP (controlled substances in most jurisdictions), it frequently falls under federal analogue acts or specific NPS legislation globally. We do not ship to regions where this compound is explicitly prohibited. By purchasing from us, you affirm that you are a qualified researcher or institutional buyer over the age of 18, and you assume all legal liability for the product upon delivery.

Frequently Asked Questions (FAQ)

Q1: What is 3-HO-PCE?
A: 3-HO-PCE (3-Hydroxyeticyclidine) is a novel synthetic arylcyclohexylamine. It is the 3-hydroxy analog of PCE and the primary active metabolite of 3-MeO-PCE. It acts primarily as a potent non-competitive NMDA receptor antagonist (dissociative), blocking the glutamate-gated ion channels in vitro.

Q2: What makes 3-HO-PCE different from 3-MeO-PCE?
A: Structurally, 3-HO-PCE features a hydroxyl (OH) group at the 3-position of the phenyl ring, while 3-MeO-PCE features a methoxy (OCH3) group. Pharmacologically, 3-HO-PCE is the active metabolite of 3-MeO-PCE; when 3-MeO-PCE enters a biological system, the liver rapidly strips the methyl group (O-demethylation) to form 3-HO-PCE. Providing the pure 3-HO-PCE allows researchers to study the exact pharmacological profile of this metabolite without the confounding variables of in-vivo metabolism.

Q3: Why choose the powder form over pellets or blotters?
A: The raw powder format offers maximum versatility for laboratory researchers. It allows for the creation of highly specific, custom-concentration volumetric stock solutions tailored to unique in-vitro assay requirements, streamlining high-throughput screening without the limitations of fixed-dose units.

Q4: Can 3-HO-PCE Powder be consumed?
A: Absolutely not. 3-HO-PCE is a potent NMDA antagonist and CNS depressant. It is sold strictly for in-vitro laboratory and analytical research. Ingestion can cause unpredictable, severe psychological and cardiovascular effects and is strictly prohibited.

Q5: Do you provide a Certificate of Analysis (CoA)?
A: Yes. We provide a comprehensive CoA—including HPLC, GC/MS, and NMR data—for every batch we sell. This guarantees the identity, purity, and mass of the compound.

Q6: Is it legal to buy 3-HO-PCE in my country?
A: Legality varies drastically by country and is subject to change. Because it is a structural analog of PCE and PCP, it is often controlled under analogue acts or specific NPS bans. We cannot provide legal advice. It is your responsibility to research your local laws regarding this compound before placing an order.

Q7: How should I store 3-HO-PCE Powder for long-term research?
A: For maximum longevity, store 3-HO-PCE powder in an airtight, amber glass vial under an inert gas (like Argon) in a freezer set to -20°C. Keep away from direct sunlight, heat, and moisture. Note: Hydroxylated compounds are more prone to oxidation than their methoxy counterparts; inert gas storage is highly recommended.